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The drenching rains and whipping winds off the Mediterranean Sea were not enough to keep Major Anwar al-Mishri in his Toyota pick-up truck. "Our patrols go out no matter what," he said, his voice barely audible over the pelting drops. "Our job is to protect the people. And that is what we are here to do tonight."
Over the past few weeks, units of the Libyan National Army such as Mishri's have stepped up their presence in the capital of Tripoli, urging regional militias to disband and join their forces. Many have scoffed at the offer, preferring instead to keep their heavy weapons. The new Libyan government is too weak to confront the brigades. It is concentrating efforts on more pressing matters, such as lobbying the international community to release its frozen assets. With the government lacking the will and motivation to confront the brigades, the creation of a national fighting force to replace the regional units scattered throughout the country is unlikely to be accomplished any time soon. (See "In the Former Rebel Capital: Benghazi Protests Libya's New Regime.")
But that doesn't deter the major. On the coastal road near the neighborhood of Suq al-Juma'a, Mishri and his 20 soldiers have set up a makeshift checkpoint. They spread out around a traffic circle with each man standing between each of the three lanes. The soldiers are looking for pick-up trucks with heavy weapons, such as missile launchers. The hundreds of brigades that sprung up during the country's eight-month long revolution pilfered the army's depots, making off with thousands of anti-tank cannons and anti-aircraft guns. Now that the revolution is over and former leader Muammar Gaddafi is dead, Libya's new government, known as the National Transitional Council (NTC), wants them to return the weapons to the barracks. "The militias need to hand the missiles over to the army, and that is why we are here," says Mishri.
In downtown Tripoli, Colonel Salim Azway is inspecting a Military Police office on Medina Street. The regional office has been busy signing up recruits for the armed forces branch. Thirty-five men enlisted at the Medina Street station over the past seven weeks. "Every day we get new people," says the colonel, sifting through a seven page list of 128 people who joined the Military Police since July. But he admits that not everyone joins out of a sense of national duty. "Some sign up for nationalistic reasons, others because they need to work." With the economy decimated by the war, many have been enticed by the promise of a steady paycheck. Married men receive 500 Libyan dinars per month ($322), and single men receive 300 dinars ($194). (Watch "Why They Protest: Egypt, Libya, and Syria.")
The Military Police verifies that everyone carrying a weapon has a permit from the National Army. Like Major Mishri's men, they set up random check points throughout the capital. They also search for high-ranking Gaddafi loyalists who served in the brigades that led the assault against the rebels during the revolution.
At Tripoli's airport, a group of militia fighters are gathered around a pick-up weighed down by an anti-aircraft gun. "Why do we need to turn in our weapons and register our guns?" Radi Jalban asks. "We liberated the country and it is our right to carry weapons." Jalban and his fellow fighters come from Zintan, a city whose warriors played a key role in liberating Western Libya. Zintani brigades subsequently encircled Tripoli and led the final assault against the loyalists. They later captured Gaddafi's son Saif al-Islam, who remains incarcerated in their hometown. They are the last remaining regional brigade in Tripoli controlling the airport and a few other pockets around the capitol.
The NTC and its National Army have not been able to persuade militias from Zintan and other cities to join the new armed forces, nor has it been able to rein them in. More interested in guarding their independence than in fostering national unity, the brigades from what are virtually city-states have rebuffed the NTC's entreaties to disband. They have also refused to allow the NTC access to prisoners, leaving the council in the dark about which senior Gaddafi officials they hold. At a recent press conference, NTC Vice Chairman Abd al-Hafiz Ghoga confessed that the government does not know where Gaddafi's intelligence chief Abdallah Sanussi is being held. The Zintani fighters holding Saif al-Islam Gaddafi have refused to surrender him to the national authorities. (See "Now Revealed: The Rebels' Secret Collaborators in Gaddafi's Tripoli.")
Militias have been accused of violence and crime in Tripoli. The mention of Zintani brigades in the capitol conjures a bitter response. "They steal cars and beat up people," carps Ahmad Fatni at a Tripoli coffee stand.
"We don't want Zintani brigades to control our roads. The police should control them," says General Khalifa Hiftar. "Zintani brigades are spread out in people's houses and farms. Why do they still control the airport?" General Hiftar has reason to be frustrated with Zintani militias. Two weeks ago they sprayed his convoy with bullets when it did not stop at a Zintani-manned checkpoint on the road to the airport. Days later they shot his son four times outside a bank and later incarcerated him before turning him over to the hospital. Says the general, "All armed groups should go home or join the army."
But the NTC is in no hurry to use force to get them to do so. Instead the government has focused on financial incentives. Council Chairman Mustafa Abd al-Jalil has been floating a plan to persuade the militias to choose among joining the army the police, or returning to civilian life. At a rally on Thursday he explained that he envisioned sending rebels to receive vocational training abroad. But with the NTC strapped for cash, such a plan is unlikely to be implemented. "We need money. Without it, we cannot build a national army and institutions," Ghoga told TIME. "Our chief priority is getting the world to unfreeze our $160 billion it holds."
If its plan to entice the militias with financial incentives proves untenable, the NTC may have to coerce the brigades to disband. But with the country trying to turn the page after eight months of fighting and bloodshed, it is a step the council is reluctant to take.
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The GSM handsets owned by as much as 80 percent of mobile phone users worldwide may be vulnerable to a new wave of sophisticated hacker attacks, according to a new study from Security Research Labs.
The Berlin-based SRL's tests, which were conducted in 11 countries, demonstrate that sophisticated cyber criminals would not find it difficult to intercept, track and impersonate the activities of GSM handset users.
Other security experts have questioned whether the threat is significant, due to the sophistication of the techniques required to launch GSM attacks, which places the technology beyond the reach of most individuals. However, SRL head Karsten Nohl warned that no one should underestimate the level of the threat that GSM handset users now face.
"We have seen university students implement GSM cracking equipment within a week using only scrap parts and free software from the Internet," Nohl said in an e-mail Tuesday.
"While an engineering background certainly is 'beyond the abilities of most individuals,' there are still millions of tech-savvy kids out there that could turn into GSM hackers overnight," Nohl said.
All GSM Networks Vulnerable
Nohl said had already succeeded in hacking into the personal phone of a consenting colleague using a GSM handset on 30 different networks in nine European Union member states, as well as three networks in Morocco and four in Thailand.
Though SRL did not conduct any network vulnerability tests within the United States, Nohl noted that American carriers such as AT&T and T-Mobile use the same GSM technology found elsewhere in the world. So far, however, few wireless carriers around the world have elected to employ a simple patch that would eliminate this security vulnerability.
Though the extent to which GSM handset users are protected from impersonation, interception and tracking attacks varies widely among the wireless carriers already tested, all of the systems Nohl tested were vulnerable to some extent.
What's more, the requisite tools for cracking GSM security keys and analyzing GSM voice traffic are available for download over the Internet. For example, a programmable radio can be used in tandem with the GnuRadio tool to record GSM over-the-air data.
SRL noted the Airprobe tool's GSM receiver is capable of decoding the GSM network's control traffic, "and in scenarios where no encryption is used -- or where the encryption key is known -- [Airprobe] also decodes voice traffic." By contrast, the purpose of the Kraken utility for PCs is to search through recorded cellular traffic and extract the secret key for breaking GSM's A5/1 encryption.
The Best Defense
SRL is encouraging wireless carriers to use GnuRadio, Airprobe, Kraken and other tools to gauge the extent to which their networks are vulnerable. The security firm also recommends the deployment of the short-term protocol patches currently available, which make cracking GSM significantly harder than it is right now.
In the long run, however, SRL said, the best defense is for carriers to migrate to newer wireless technologies. The venerable GSM standard also known as 2G does "not provide sufficient security and stronger alternatives such as UMTS (3G) and LTE (4G) should be preferred," the security firm said.
According to Nohl, the voice mail hacking done in the past -- such as the alleged hacking of phones by journalists in the United Kingdom -- prompted operators to upgrade their defenses. "They now more diligently check the caller ID and set not-predictable pin codes," Nohl said.
The new attacks about which Nohl is warning, however, would be able to circumvent these new protection measures. "Fortunately, the one newspaper that would have wanted this privacy-intruding capability did not live to witness today's release," Nohl said of Rupert Murdoch's News of the World. The newspaper closed last summer after revelations of illegal wiretapping.
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What were the biggest stories to hit the?competitive?fighting game community this year? With so much having happened, it?s hard to decide. These are the top ten biggest stories according to Get Your Tournament.
5. Filipino Champ wins Northwest Majors 3?and Canada Cup
4. Majors for Team Spooky
3. Wolfkrone and Latif burn through opponents
2. Canada Cup steals the show
1. The defense of competitive gaming
They also give an honorable mention to the following stories:
To read their full rundown of each event that made the list, head on over to GYTnews. What about you? What are your top five fighting game stories of 2011?
- OnlineTony wins seven tournaments in a row
- Japan?s unsuccessful attempt to overtake the United States in Marvel vs. Capcom 3 at Evolution 2011
- Daigo Umehara?s Super Street Fighter IV title reign at Evolution ends
- The struggle against top-tier characters
- Perfect Legend wins at Evolution 2011
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New York ? The Nebraska senator won't seek a third term, raising questions about the Left's chances of holding onto its slim Senate majority
Senate Majority Leader Harry Reid may have trouble hanging onto his majority title in the 113th Congress. On Tuesday, Sen. Ben Nelson (D-Neb.) became the latest moderate Democrat (following Kent Conrad and Jim Webb, among others) to announce that he won't seek another term in the 2012 election. Nelson, who faced an uphill battle for a third term, is the sole Democrat in Nebraska's five-member congressional delegation, and many political analysts believe his red-state seat could now be a relatively easy Republican pickup. The GOP is working hard to wrest control of the Senate from the Dems in 2012, and only has to net four seats to flip the Dems' 53-47 majority in the 100-member Senate. Is Nelson's retirement a "significant blow" to Dems, or no biggie since he would have likely lost his re-election bid anyway?
This is a big loss for Dems:?Nelson's retirement "puts Republicans one seat closer to a majority," Cook Political Report's Jennifer Duffy?tells Bloomberg. I simply "don't see a path to victory for Democrats in Nebraska." Nelson is hardly perfect, Rothenberg Political Report's Nathan Gonzales tells Bloomberg, but he was the Dems' best bet in the Cornhusker State. And remember, Democrats are already "defending eight out of the 10 most competitive seats in the country." This is a "significant blow" in the Left's quest to keep the Senate.
"Nelson's retirement hurts Senate Dems' in 2012"
But Nelson would have lost anyway: This isn't such a big deal, says Ed Morrissey at Hot Air. Though I'm reluctant "to underestimate the power of incumbency," you can bet Nelson wouldn't have been re-elected in this "very red state." "The man couldn't even eat a pizza in peace after casting a decisive vote for ObamaCare and tossing his pro-life credentials into the wastebasket by doing so." He would have surely been replaced by "a credible Republican candidate." This development doesn't change "the calculus in Nebraska."
"Breaking: Nelson to retire"
This might even be good for Dems:?Of course, this looks "like a very tough break for Team Blue,"?says David Nir at the?Daily Kos. But?there could be "a silver lining."?If "Nelson really had no hope of winning another term, then a ton of resources would have been wasted on a futile attempt to save him." Now, if losing his seat is a foregone conclusion, Democrats can focus on defending seats they actually have a chance of keeping, not to mention helping new candidates, like Shelley Berkley in Nevada and Elizabeth Warren in Massachusetts, who stand a chance of picking up new seats.
"NE-Sen: Democrat Ben Nelson reportedly will announce retirement"
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Presidential primary history tells us that there is little chance that the all seven of the remaining Republican candidates running for the White House will make it to Florida?s Jan. 31 presidential primary.
In 2008, the much-hyped Fred Thompson, a former U.S. Senator from Tennessee, flamed out a week before Florida?s primary after finishing well back in South Carolina?s pivotal primary. And lesser known long shot Duncan Hunter packed it in after finishing dead last in the Nevada caucus before Florida voted.
That knocked the Republican field from eight to six candidates by the time the GOP rolled into the Sunshine state. Rudy Giuliani?s Florida or bust strategy came to an inglorious end after his disappointing finish here.
So who are the candidates most likely to be gone by the time Florida votes this time?
Here?s my list, ranked from most likely to least likely to drop out before Florida Republicans go to the polls on Jan. 31.
1. Rick Santorum: The former Pennsylvania senator has everything riding on Iowa. He?s got at least 13 paid staffers in Iowa, according to Campaigns & Elections magazine. That?s more than any of the other contenders.
Santorum is trying to tap the Evangelical base that helped deliver Iowa to surprise 2008 caucus winner Mike Huckabee. If Santorum does not finish in the top three in Iowa, he may not have the money to get much further.
And the polls don?t look good for him. Most of the polls coming out of Iowa have him still in the single digits, battling to stay out of last place with Jon Huntsman.
2. Jon Huntsman: While Santorum has everything riding on Iowa, the former Utah governor has his fate dependent on New Hampshire. Huntsman has 13 paid staffers in the Granite State, and has his national headquarters there. No other candidates have more than 10 paid staffers.
Huntsman needs a big showing in New Hampshire, yet polls show he is still struggling to break through. Most polls in New Hampshire this month show he?s hovering in fourth place.
3. Michele Bachmann: The Minnesota Congresswoman is close to being in the same position as Santorum, but has been polling better in Iowa since the summer. She has to do well because she barely has a pulse in New Hampshire where her entire staff quit earlier in the fall.
4. Rick Perry: The Texas governor is most resembling of Thompson from 2008. If Perry cannot crack top three in Iowa, New Hampshire or South Carolina, he?s likely toast. The polls right now suggest that it is very likely he will finish out of top three in all three of them.
The one thing that could keep him in longer is that he?s had more money in his campaign account than most of the other candidates. That could give him the ability to weather poor showings in Iowa and New Hampshire better than other candidates.
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MOSCOW ? Tens of thousands of Russians jammed a Moscow avenue Saturday to demand free elections and an end to Prime Minister Vladimir Putin's 12-year rule, in the largest show of public outrage since the protests 20 years ago that brought down the Soviet Union. Gone was the political apathy of recent years as many shouted "We are the Power!"
The demonstration, bigger and better organized than a similar one two weeks ago, and smaller rallies across the country encouraged opposition leaders hoping to sustain a broad protest movement ignited by a fraud-tainted parliamentary election on Dec. 4.
The enthusiasm also cheered Mikhail Gorbachev, the last Soviet leader who closed down the Soviet Union on Dec. 25, 1991.
"I'm happy that I have lived to see the people waking up. This raises big hopes," the 80-year-old Gorbachev said on Ekho Moskvy radio.
He urged Putin to follow his example and give up power peacefully. If Putin stepped down now, he would be remembered for the positive things he did, Gorbachev said. The former Soviet leader, who has grown increasingly critical of Putin, has little influence in Russia today.
But the protesters have no central leader and no candidate capable of posing a serious challenge to Putin, who intends to return to the presidency in a March vote. In a fair election, the veteran Communist Party leader would pose the strongest threat, and he has joined the Kremlin in disparaging the protests.
Even at Saturday's rally, some of the speakers were jeered by the crowd. The various liberal, nationalist and leftist groups that took part appear united only by their desire to see "Russia without Putin," a popular chant.
Putin, who gave no public response to the protest Saturday, initially derided the demonstrators as paid agents of the West. He also said sarcastically that he thought the white ribbons they wore as an emblem were condoms. Putin has since come to take their protests more seriously, and in an effort to stem the anger he has offered a set of reforms to allow more political competition in future elections.
Kremlin-controlled television covered Saturday's rally, but gave no air time to Putin's harshest critics.
Estimates of the number of demonstrators ranged from the police figure of 30,000 to 120,000 offered by the organizers. Demonstrators packed much of a broad avenue, which has room for nearly 100,000 people, about 2.5 kilometers (some 1.5 miles) from the Kremlin, as the temperature dipped well below freezing.
A stage at the end of the avenue featured banners reading "Russia will be free" and "This election Is a farce." Heavy police cordons encircled the participants, who stood within metal barriers, and a police helicopter hovered overhead.
Alexei Navalny, a corruption-fighting lawyer and popular blogger, electrified the crowd when he took the stage. He soon had the protesters chanting "We are the power!"
Navalny spent 15 days in jail for leading a protest on Dec. 5 that unexpectedly drew more than 5,000 people and set off the chain of demonstrations.
Putin's United Russia party lost 25 percent of its seats in the election, but hung onto a majority in parliament through what independent observers said was widespread fraud. United Russia, seen as representing a corrupt bureaucracy, has become known as the party of crooks and thieves, a phrase coined by Navalny.
"We have enough people here to take the Kremlin," Navalny shouted to the crowd. "But we are peaceful people and we won't do that ? yet. But if these crooks and thieves keep cheating us, we will take what is ours."
Protest leaders expressed skepticism about Putin's promised political reforms.
"We don't trust him," opposition leader Boris Nemtsov told the rally, urging protesters to gather again after the long New Year's holidays to make sure the proposed changes are put into law.
He and other speakers called on the demonstrators to go to the polls in March to unseat Putin. "A thief must not sit in the Kremlin," Nemtsov said.
The protest leaders said they would keep up their push for a rerun of the parliamentary vote and punishment for election officials accused of fraud, while stressing the need to prevent fraud in the March presidential election.
Former world chess champion Garry Kasparov was among those who sought to give the protesters a sense of empowerment.
"There are so many of us here, and they (the government) are few," Kasparov said from the stage. "They are huddled up in fear behind police cordons."
The crowd was largely young, but included a sizable number of middle-aged and elderly people, some of whom limped slowly to the site on walkers and canes.
"We want to back those who are fighting for our rights," said 16-year-old Darya Andryukhina, who said she had also attended the previous rally.
"People have come here because they want respect," said Tamara Voronina, 54, who said she was proud that her three sons also had joined the protest.
Putin's comment about protesters wearing condoms only further infuriated them and inspired some creative responses. One protester Saturday held a picture montage of Putin with his head wrapped in a condom like a grandmother's headscarf. Many inflated condoms along with balloons.
The protests reflect a growing weariness with Putin, who was first elected president in 2000 and remained in charge after moving into the prime minister's seat in 2008. Brazen fraud in the parliamentary vote unexpectedly energized the middle class, which for years had been politically apathetic.
"No one has done more to bring so many people here than Putin, who managed to insult the whole country," said Viktor Shenderovich, a columnist and satirical writer.
Two rallies in St. Petersburg on Saturday drew a total of 4,000 people.
"I'm here because I'm tired of the government's lies," said Dmitry Dervenev, 47, a designer. "The prime minister insulted me personally when he said that people came to the rallies because they were paid by the U.S. State Department. I'm here because I'm a citizen of my country."
Putin accused the United States of encouraging and funding the protests to weaken Russia.
Putin's former finance minister surprised the protesters by saying the current parliament should approve the proposed electoral changes and then step down to allow new parliamentary elections to be held. Alexei Kudrin, who remains close to Putin, warned that the wave of protests could lead to violence and called for establishing a dialogue between the opposition and the government.
"Otherwise we will lose the chance for peaceful transformation," Kudrin said.
Kudrin also joined calls for the ouster of Central Election Commission chief Vladimir Churov.
Putin has promised to liberalize registration rules for opposition parties and restore the direct election of governors he abolished in 2004. Putin's stand-in as president, Dmitry Medvedev, spelled out those and other proposed changes in Thursday's state-of-the nation address.
Gorbachev, however, said the government appears confused.
"They don't know what to do," he said. "They are making attempts to get out of the trap they drove themselves into."
____
Associated Press writers Nataliya Vasilyeva and Jim Heintz contributed to this report.
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Are you finished with your holiday shopping yet?
Well, at this point, GOOD LUCK ? but if you are gifting someone who will not judge you for belated, you have to check out this iPhone photo printer I discovered ? how many of your photos sadly never make it anywhere except the album in your phone?
NOW imagine you can take that iPhone, dock it into your printer, and print those special photos? Amazing, right???
Photo Cube iPhone Photo Printer ($100)
Source: http://mygloss.com/geek/accessories/gloss-find-photo-cube-iphone-photo-printer/
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The average rate on the 30-year fixed mortgage has dropped to 3.91 percent, a record low, Freddie Mac said Thursday. Here's a look at rates for fixed- and adjustable-rate mortgages over the past 52 weeks. |
Current week's average Last week's average 52-week high 52-week low |
30-year fixed 3.91 3.94 5.05 3.91 |
15-year fixed 3.21 3.21 4.29 3.21 |
5-year adjustable 2.85 2.86 3.92 2.85 |
1-year adjustable 2.77 2.81 3.40 2.77 |
All values are in percentage points. |
Source: Freddie Mac Primary Mortgage Market Survey. |
Copyright ? 2011 The Associated Press. All rights reserved. The information contained in the AP News report may not be published, broadcast, rewritten or redistributed without the prior written authority of The Associated Press.
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HOUSTON (Reuters) ? Financier Allen Stanford was judged mentally fit to stand trial by a federal judge on Thursday, setting the stage for a trial next year in one of the biggest white-collar fraud cases since Bernard Madoff.
Stanford, 61, is accused of operating a $7 billion Ponzi scheme that bilked investors throughout the United States and Latin America.
He has been in federal custody since his arrest in June 2009 after being considered a flight risk.
District Judge David Hittner in Houston said a "preponderance of evidence" presented in a three-day hearing convinced him Stanford is capable of helping his attorneys prepare for trial.
Lawyers for Stanford argued unsuccessfully that their client suffers from a lasting brain injury from a jailhouse attack in September 2009, serious depression and said drugs administered after the brain injury have impaired his memory.
Prosecutors contended Stanford exaggerated his amnesia and they wanted his trial to start as scheduled in January.
Stanford looked back and waved at his mother, 81-year-old Sammie Stanford, as he was taken from the courtroom after the judge read his brief order.
Hittner said he would rule next week on a defense motion to delay the beginning of Stanford's trial for four months.
Stanford, who once ran the Stanford Financial Group and owned luxury homes in the Caribbean, Houston and Miami, was indicted on charges of fraud, conspiracy and money laundering. He pleaded not guilty.
He is accused of running a Ponzi scheme involving the sale of fraudulent certificates of deposit issued by his offshore bank in Antigua. A Ponzi scheme is a fraud in which existing investors are paid with money from newer ones.
Hittner presided over three days of testimony on Stanford's competency after Stanford was treated for more than eight months at a prison hospital in North Carolina, where he was weaned off anti-anxiety medication and underwent psychological testing.
"Mr. Stanford doesn't want to fight," Assistant U.S. Attorney Gregg Costa said in his closing statements Thursday. "He wants to con his way out this case just like he conned investors out of their money for 20 years."
Doctors at the North Carolina facility found Stanford had "no mental illness which would interfere with his ability to understand the nature and consequences of the proceedings against him or to assist properly in his defense," according to a report to Hittner.
"I see no brain injury that stands in the way of his standing trial," Dr. Robert Cochrane, Stanford's primary evaluator at the Butner federal prison hospital, testified.
Witnesses for Stanford, however, said doctors at the federal facility downplayed the severity of Stanford's brain injury and mental problems.
They said he suffers post-traumatic stress disorder, major depression and insomnia, among other problems, that would make it hard for him to concentrate, analyze information or testify in his own behalf.
"The clinical diagnosis is very important to treatment decision as well as legal decisions such as in this court," said Dr. David Axelrad, a forensic psychiatrist testifying for Stanford.
His attorneys said he would be unable to help them analyze a the massive amount of information related to his investment business.
"He can't get on the witness stand," Ali Fazel, a Stanford attorney, told the judge. "The fundamental right he has, he doesn't have the ability to do."
After the ruling, Stanford attorney Robert Scardino declined to comment on Hittner's decision, citing a gag order.
"We will continue to get ready for trial," Scardino said.
Stanford spent the night under psychological observation after a neuropsychologist testifying for the defense on Wednesday said Stanford had been suicidal at some period since his arrest.
Jail officials said in court they acted with "an abundance of caution" after the testimony on Wednesday.
Stanford's mother, Sammie, denied her son is suicidal.
"That is laughable," she told reporters after the hearing. "My son is not suicidal."
Stanford was moved to a more secure room but not put under suicide watch, staff attorney Jennifer Hansen of the federal detention center in Houston, told the judge. She said she had requested that Stanford be under psychological observation again Thursday night.
(Reporting by Eileen O'Grady in Houston; editing by Martha Graybow, Steve Orlofsky and Andre Grenon)
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Apple chief executive officer Steve Jobs and author Christopher Hitchens, who both recently succumbed to their respective cancers, were among a select few cancer patients to have their entire genomes sequenced. Doctors were hoping to tailor each man's cancer treatment by identifying genetic mutations within the cancer that might be treatable with certain drugs ? an approach known as personalized medicine.
But even after cracking the genetic code, the attempted treatments were not cures. While researchers have made quite a bit of progress with personalized treatments for cancer in recent years, we still have a long way to go, experts say.
For some cancers, such as breast cancer and melanoma, researchers have identified groups of people who respond well to drugs because of the genetic makeup of their cancer cells. In fact, in some cases of leukemia, tailored drugs can keep the cancer in check for many years, said Marc Symons, a cancer researcher at the Feinstein Institute for Medical Research in Manhasset, N.Y.
But for others, the benefit is incremental, extending lifespan by only a few months. And many patients aren't candidates for tailored drugs at all.
"We're much better than we were a decade ago," at treating cancer patients with individualized therapies, said Dr. Daniel Budman, interim chief of hematology/oncology at the Monter Cancer Center, in Lake Success, N.Y. "But unfortunately, a lot of people are still dying of cancer," Budman said.
Researchers are exploring many avenues to personalized cancer treatment. Ultimately, they hope to better understand cancer itself, what makes it grow, and how people's individual reactions to cancer make a difference in terms of treatment, Budman said.
"As the knowledge progresses, we get a little smarter about how we treat [patients] rather than indiscriminately [treating] everyone the same," Budman said.
Whole genome sequencing: Looking for a needle in a haystack
To date, hundreds patients have had their entire genome sequenced for a cancer treatment, Symons said. This approach is rare because sequencing a genome is expensive ? around $10,500, according to the National Institutes of Health ? and patients must also have their tumor's genome sequenced (doubling the cost) in order for doctors to compare the mutations in a tumor with those in the rest of a person's cells.
However, the cost of genome sequencing is rapidly coming down, and Symons said he does not expect this to be a barrier for long.
The biggest challenge is figuring out how to treat the patient once you know the whole genome, Symons said. Researchers must know which mutations are relevant to the cancer's progression, which are susceptible to treatment, and which drugs should be used to target them, Symons said. "That?s still a black box to a large extent," he said.
Hopefully, as we sequence more individual genomes, we'll learn more about what makes certain people susceptible to cancer, and what makes some people better at fighting cancer, Budman said.
Target mutations: Changing our view of late-stage cancers
Breast cancer, lung cancer, leukemia and melanoma are just a few ?examples of cancers in which specific mutations have been found that can make a tumor susceptible to treatment with certain drugs. In these cases, researchers simply test whether the particular mutation is present ? they don't need to sequence the whole genome, Symons said.
However not all patients with these cancers will have a drug-susceptible mutation. For example, about 50 percent of patients with melanoma have a carcinogenic mutation in a gene called BRAF, and about 10 percent of patients with lung cancer have a mutation in a gene called EGRF. In both cases, drugs have been developed to counter the deleterious effects of the mutation, but for patients without those mutations, the drugs have no effect.
This type of personalized medicine is changing how we think about and diagnose cancer, Symons said. Traditionally, cancer was diagnosed by examining the cancer tissue under a microscope, and assessing whether a tumor has spread to other organs. But researchers are shifting towards a molecular classification of cancers, which categorizes them based on genetic mutations and other molecular characteristics, Symons said.
Drugs that target the right mutations could improve a patient's outcome, even if the cancer is in advanced stage, Symons said. Eventually, such therapies may change the way people think about late-stage cancer, from a disease that's often incurable to one that can be managed.
Future cancer treatments
Another approach to personalized medicine is to take a piece of cancer tissueout of the patient, and grow the cancer cells in lab dishes, Symons said. This allows scientists to test out many different drugs on an individual's cancer to see which ones work best. A similar strategy is to put cells from a patient's cancer in an animal before testing drugs. So far, this approach has not been used in individual patients, Symons said, but it will be soon.
Some say this strategy has a limited value because human cancers grow in the human body and interacting with the body's chemistry, Budmansaid.
"You don?t treat the cancer as just an isolated cell. You treat the cancer knowing it's interacting with that patient," Budman said.
For instance, researchers may aim to interfere with the blood supply to the tumor, or boost a patients' immune response to the disease, in order to treat it, Budman said. The best treatments may ultimately be combinations of therapies that together weaken the tumor, and enhance a patient's ability to fight it, he said.
Pass it on: For some cancers, tailored treatments are available, but researchers must better understand cancer, and how it acts inside an individual, before personalized medicine truly takes off.
This story was provided by MyHealthNewsDaily, a sister site to LiveScience. Follow MyHealthNewsDaily staff writer Rachael Rettner on Twitter @RachaelRettner. Find us on Facebook.
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FORT MYERS, Fla. ? The mother of country singer Mindy McCready wants her grandson back.
Gayle Inge and her husband, Michael Inge, said Thursday in a news release that their 5-year-old grandson Zander should be returned to them in Florida.
Under Florida law, Inge is Zander's legal guardian. In November, McCready took the boy out of Florida without the permission of Florida's courts. The singer and her son were found in Arkansas. McCready told The Associated Press that she took the boy because she feared he was being abused at her mother's home; Gayle Inge has denied the allegations.
Zander is currently in the custody of Arkansas child welfare authorities. The Inges say Arkansas shouldn't have jurisdiction over the case and that being away from his Florida family isn't in the boy's best interest.
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MOSCOW, Dec 16 (Reuters) - Russian President Dmitry Medvedev confirmed acting Finance Minister Anton Siluanov in the post on Friday, nearly three months after long-serving Finance Minister Alexei Kudrin was forced to quit the government.
The announcement suggests that Medvedev, who is expected to become prime minister after Vladimir Putin's likely election to the presidency next March, will be core member of Medvedev's future government team.
Siluanov, a low-profile career finance ministry official, said his department was readying anti-crisis measures and was ready 'for different scenarios'.
He described the liquidity situation in the banking system as 'acute', said the ministry exercise restraint in its borrowing and that it had prepared measures to deploy its financial reserves should the situation deteriorate.
(Reporting by Denis Dyomkin,; Writing by Andrey Ostroukh, Editing by Douglas Busvine) Keywords: RUSSIA FINMIN/
(andrey.ostroukh@thomsonreuters.com)(+7 495 775 1242)
COPYRIGHT
Copyright Thomson Reuters 2011. All rights reserved.
The copying, republication or redistribution of Reuters News Content, including by framing or similar means, is expressly prohibited without the prior written consent of Thomson Reuters.
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WASHINGTON ? House Republicans will stick to their insistence that a bill extending a payroll tax cut and jobless benefits include language speeding work on a controversial oil pipeline, Speaker John Boehner said Friday.
The remarks by Boehner added a contentious backdrop to negotiations over a compromise payroll tax cut measure. With President Barack Obama and many congressional Democrats opposed to accelerating work on the proposed Keystone XL pipeline, which would run for 1,700 miles from western Canada to Texas, that conflict has been one of the major hurdles to a bipartisan deal on the payroll tax package.
Meanwhile, the House began debating a $1 trillion spending bill that would avert a partial federal shutdown beginning Saturday. That measure, which would finance dozens of federal agencies through next September, would replace a stopgap spending bill that expires at midnight Friday and is sure to pass.
Negotiations on the payroll tax cut legislation between Senate Majority Leader Harry Reid, D-Nev., and Senate Minority Leader Mitch McConnell, R-Ky., were continuing Friday. Leaders are hoping that Congress will finish that bill and others and end its work for the year in the next few days.
Reid said Friday that bargainers were making good progress in those talks, a sentiment echoed by McConnell.
"The majority leader and I are making significant progress on reaching agreement on a package that will have bipartisan support, I hope," McConnell said. "I think we're going to get to that place."
With those talks under way, House leaders planned to send their members home after finishing their work Friday, with plans to return when the Senate produces a payroll tax cut measure for the House to vote on.
But Boehner, R-Ohio, struck a combative tone following a closed-door meeting Friday morning of House Republicans.
"I guarantee that the Keystone pipeline will be in there when it goes back to the United States Senate," Boehner said.
This year's 4.2 percent payroll tax rate will jump back to its normal 6.2 percent on Jan. 1 unless action is taken by Congress. Few lawmakers want to be blamed for a tax increase that would affect 160 million people.
Extended benefits for long-term jobless people will also expire Jan. 1 without congressional action.
That same day, a 27 percent cut in Medicare reimbursements to doctors would take effect unless lawmakers act, a reduction that could convince some doctors to stop treating Medicare patients.
Even without the Keystone dispute, bargainers had still not reached agreement on how to extend a payroll tax cut through 2012, with major disputes remaining over how to finance the package.
Because of their ongoing disagreements, Senate leaders have prepared a shorter, two-month extension of the payroll tax cut and jobless benefits to give themselves more time to reach an agreement.
The two-month payroll tax cut bill would also delay the Medicare cuts for two months.
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DES MOINES, Iowa ? Republican presidential candidate Newt Gingrich has little choice but to rely on momentum to carry him to victory in the Iowa caucuses.
He has a skeleton campaign organization in a state where successful caucus candidates typically have had well-built machines aimed at turning out supporters. To build a stronger operation with less than three weeks until the leadoff 2012 contest, he has to scramble.
The former House speaker is hoping the typical rules don't apply to him, in a campaign that already has been far from typical.
"You're not going to have a successful campaign in the caucuses on organization alone," said John Stineman, an uncommitted Iowa Republican who ran Steve Forbes' 2000 caucus campaign. "You have to have some heat. Newt's getting hot at the right time. It's a matter of whether he can sustain the heat."
Getting a winning share of support from caucus goers in 1,774 precinct-level party meetings across the state on a cold, early January night requires some level of coordination, such as nailing down supporters in each of Iowa's 99 counties.
Gingrich, whose mass staff departures in June stunted his Iowa campaign, is trying to cobble together his Iowa team using emerging social media methods and time-tested grass-roots work.
He has only nine staffers in Iowa, fewer than most of his rivals. He opened his campaign office just two weeks ago, while others have had state headquarters for months. And while Gingrich's fundraising has picked up, he hasn't had the vast sums former Massachusetts Gov. Mitt Romney and Texas Gov. Rick Perry have had at their disposal.
But just as his late rise in Iowa has had more to do with his performance in the national debates than campaigning in the state, his Iowa organization is benefiting from the notice he's sparked nationally.
Gingrich has argued that his message, timing and the Internet can help him close the organizational gap.
His full-frontal attack on President Barack Obama has been what some GOP activists in Iowa say is the confrontational approach they've been looking for in a potential challenger to the well-funded incumbent.
Gingrich, who has asked his supporters to remain positive as he faces attacks, is on the air in Iowa with a positive spot. Time is running out for effective advertising messages to stick, with candidates unlikely to air attack ads over the holidays.
He rolled out a new TV ad on Thursday that chides his rivals for going negative.
"These are challenging and important times for America. We want and deserve solutions," Gingrich says. "Others seem to be more focused on attacks rather than moving the country forward. That's up to them."
"I believe bold ideas and new solutions will unleash America's creative spirit," Gingrich adds.
Gingrich's message attacking Obama and pledging a positive campaign versus his GOP rivals has helped bring potential supporters to his website. It has netted supporters around the country who have made, on average, 1,200 telephone calls per night to Iowa Republicans in the past week, Gingrich deputy Iowa director Katie Koberg said.
Through the same site, a dozen supporters from out of state have traveled to Iowa to log days helping the campaign, Koberg said.
It's a far cry from Texas Rep. Ron Paul's campaign, with its statewide supporter network that includes niche groups such as students and doctors.
Although Romney has campaigned in Iowa less often than he did four years ago, his team has kept after supporters of his 2008 campaign, a massive $10 million effort that earned him second place.
That year, former Arkansas Gov. Mike Huckabee won the caucuses with a threadbare staff. He was the overwhelming favorite of evangelical Christian conservatives, who functioned as an influential network but were not necessarily organized by the Huckabee campaign.
Gingrich is not the unanimous favorite of evangelicals, but he has the momentum Huckabee did.
"You can't confuse organization with paid staff," said Tim Albrecht, who was Romney's 2008 Iowa campaign spokesman but is uncommitted this year. "Gingrich has a Huckabee quality to him ? late getting in place but with a ready audience, those longtime caucus veterans who don't need any hand-holding to get them to caucus."
Given the fluidity demonstrated in Iowa polls, Gingrich could benefit from late-deciding caucus goers. And he has picked up a number of key GOP activists. The campaign rolled out a list of them from across the state and different segments of the party late Wednesday, aimed at portraying Gingrich as a unifying candidate.
They include former Iowa Republican Party Chairman Ray Hoffmann and Dean Kleckner, former president of the American Farm Bureau Federation. Kleckner had been a top Iowa backer of Herman Cain before the Georgia businessman quit the race Dec. 3.
Another key pickup known for his organizational heft is Darryl Kearny, a former finance director of the Iowa Republican Party and now the key finance official for Polk County, Iowa's most populous.
"I realize they have a lot of catching up to do," said Kearny, who has amassed a massive Rolodex in his 30-plus years as an Iowa party activist and campaign operative. "But I'm networking with everyone I know, calling and emailing, trying to pass on the word about Newt."
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China's manufacturing activity continued to contract in December, banking giant HSBC says, as exports are hurt by the ongoing crises in the crucial US and European markets.
The preliminary HSBC purchasing managers' index (PMI) reached 49 in December, slightly better than the 47.7 in November, as consumers from New York to Paris cut back on holiday spending due to the dire outlook.
A reading above 50 indicates the sector is expanding while a reading below 50 suggests a contraction. The final figure will be released on December 30.
The data adds to mounting evidence that export-driven China is slowing and will ratchet up pressure on Beijing to further loosen policies to prevent a painful hard landing in the world's second largest economy.
"With inflation quickly shifting to disinflation, the Chinese government can and should make more aggressive easing on both fiscal and monetary fronts to stabilise growth and jobs," HSBC chief economist Qu Hongbin said.
Qu also warned that "growth momentum remains weak with additional downside risks from exports and the property market not yet fully filtering through".
But Chinese leaders on Wednesday vowed to maintain a "prudent monetary policy and proactive fiscal policy" in 2012, suggesting they will move cautiously to open credit valves.
Beijing is anxious to prevent a sharp slowdown in the economy but at the same time it wants to avoid reigniting inflation, which hit a more than three year high of 6.5 per cent in July and has the potential to trigger unrest.
Late last month China cut the amount of money banks must hold in reserve for the first time in three years to spur lending and counter turmoil in Europe and the United States that threatens to derail the economy.
Manufacturing activity contracted in November for the first time in 33 months, while consumer prices rose at their weakest pace in more than a year and industrial output growth hit its lowest level in more than two years.
Keep reading - next articleSource: http://finance.ninemsn.com.au/newsbusiness/aap/8390415/china-manufacturing-activity-shrinking
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With Ricky Gervais set to serve as host once again, we know the 2012 Golden Globe Awards - which will air on January - will bring the humor.
But who will actually take home the trophies? Nominees from the world of film and television were announced this morning. They are...
Best Drama
The Descendants
The Help
Hugo
The Ides of March
Moneyball
War Horse
Best Comedy/Musical
50/50
The Artist
Bridesmaids
Carnage
Midnight in Paris
My Week with Marilyn
Best Animated Film
Arthur Christmas
Cars 2
Rango
Puss in Boots
The Adventures of Tintin
Best Actor in a Drama
George Clooney, The Descendants
Brad Pitt, Moneyball
Ryan Gosling, The Ides of March
Michael Fassbender, Shame
Leonardo DiCaprio, J. Edgar
Best Actor in a Comedy or Musical
Jean Dujardin, The Artist
Brendan Gleeson, The Guard
Joseph Gordon-Levitt, 50/50
Ryan Gosling, Crazy, Stupid, Love.
Owen Wilson, Midnight in Paris
Best Supporting Actor in a Motion Picture
Kenneth Branagh, My Week With Marilyn
Albert Brooks, Drive
Jonah Hill, Moneyball
Christopher Plummer, Beginners
Viggo Mortensen, A Dangerous Method
Best Actress in a Drama
Glenn Close, Albert Nobbs
Viola Davis, The Help
Rooney Mara, The Girl With the Dragon Tattoo
Meryl Streep, The Iron Lady
Tilda Swinton, We Need to Talk About Kevin
Best Actress in a Musical or Comedy
Jodie Foster, Carnage
Charlize Theron, Young Adult
Kristen Wiig, Bridesmaids
Michelle Williams, My Week with Marilyn
Kate Winslet, Carnage
Best Supporting Actress in a Motion Picture
Shailene Woodley, The Descendants
Octavia Spencer, The Help
Janet McTeer, Albert Nobbs
Berenice Bejo, The Artist
Jessica Chastain, The Help
Best Director
Woody Allen, Midnight in Paris
George Clooney, The Ides of March
Michel Hazanavicius, The Artist
Alexander Payne, The Descendants
Martin Scorsese, Hugo
Best Screenplay for a Motion Picture
Woody Allen, Midnight in Paris
Michel Hazanavicius, The Artist
Alexander Payne, Nat Faxon, Jim Rash, Kaui Hart Hemmings, The Descendants
Steve Zallian, Aaron Sorkin, Stan Chervin, Michael Lewis, Moneyball
George Clooney, Grant Heslov, Beau Willimon, The Ides of March
Best TV Comedy or Musical
Enlightened
Episodes
Glee
Modern Family
New Girl
Best Mini-Series or Motion Picture
Cinema Verite
Downton Abbey
The Hour
Mildred Pierce
Too Big To Fail
Best Actor in a TV Drama
Bryan Cranston, Breaking Bad
Steve Buscemi, Boardwalk Empire
Damian Lewis, Homeland
Jeremy Irons, The Borgias
Kelsey Grammer, Boss
Best Actor in a TV Musical or Comedy
Alec Baldwin, 30 Rock
David Duchovny, Californication
Johnny Galecki, The Big Bang Theory
Thomas Jane, Hung
Matt LeBlanc, Episodes
Best Supporting Actor in TV Series, Mini-Series, or Made-for-TV Movie
Peter Dinklage, Game of Thrones
Paul Giamatti, Too Big To Fail
Guy Pearce, Mildred Pierce
Tim Robbins, Cinema Verite
Eric Stonestreet, Modern Family
Best Actress in a TV Drama
Claire Danes, Homeland
Mireille Enos, The Killing
Julianna Margulies, The Good Wife
Madeleine Stowe, Revenge
Callie Thorne, Necessary Roughness
Best Actress in a TV Musical or Comedy
Laura Dern, Enlightened
Zooey Deschanel, New Girl
Tina Fey, 30 Rock
Laura Linney, The Big C
Amy Poehler, Parks and Recreation
Best Supporting Actress in TV Series, Mini-Series, or Made-for-TV Movie
Jessica Lange, American Horror Story
Kelly Macdonald, Boardwalk Empire
Maggie Smith, Downton Abbey
Sofia Vergara, Modern Family
Evan Rachel Wood, Mildred Pierce
Source: http://www.thehollywoodgossip.com/2011/12/2012-golden-globe-awards-and-the-nominees-are/
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This platform extension shows how Global iPlayer isn?t just about moving TV to tablet devices, it?s also about...
Source: http://feedproxy.google.com/~r/TheIphoneBlog/~3/UouPmIazXAI/story01.htm
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iOS: When you make healthy eating a part of your lifestyle, you also commit yourself to keeping track of how much you eat and how many calories you ingest so you can burn it off later with healthy exercise. However, calorie counting is the last thing most of us want to do, and FoodTrackerPro for iOS helps you keep track of your diet and overall consumption without forcing you to imput specific calorie amounts with every meal.
After every meal, open FoodTrackerPro. The app will ask you what you've eaten, and whether you've eaten a quarter, half, or whole serving of that food. The app does the math for you based on what it already knows about most types of food, and will keep track of your progress over time. If you want to make sure you get three to five servings of fruits and vegetables each day, the app will help you get there. If you're worried you're eating too many servings of bread or pasta over the course of a week, the app will show you that too.
If you're eating something the app is unfamiliar with, you can always add your own custom foods with their own nutrition information to make sure they're counted as well. After using the app for a few days or weeks, you'll get a full picture of your diet over time. The app has been around for a while, but it's a great way to track your meals on your mobile device, and it'll set you back $1.99 in the iTunes App Store. Do you use another application to track your caloric intake, or stick to a diet? Share your favorite in the comments below.
FoodTrackerPro | iTunes App Store
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ROME (Reuters) ? Prime Minister Mario Monti met unions on Sunday to build support before the cabinet approves a 20-billion-euro package of austerity measures aimed at shoring up Italy's strained finances and stemming a crisis that threatens to overwhelm the euro zone.
Ministers are scheduled to sign off on the package of tax increases and spending cuts on Monday, though sources in the prime minister's office said the cabinet meeting may be brought forward to Sunday afternoon.
Expected measures include an increase in the retirement age for many workers, liberalization of professional services, a hike in income tax for higher income brackets and new taxes on private assets and housing.
The measures come at the start of one of the most crucial weeks since the creation of the single currency more than a decade ago with European leaders due to meet on Thursday in Brussels to try to agree a broader rescue plan for the bloc.
Italy, with a public debt of around 120 percent of gross domestic product, has been at the centre of Europe's debt crisis since yields on its 10-year bonds shot up to around 7 percent, similar to levels seen when countries such as Greece and Ireland were forced to seek a bailout.
Adoption of the package is seen as vital for re-establishing Italy's shattered credibility with financial markets after a series of unfulfilled promises by the previous centre-right government of former Prime Minister Silvio Berlusconi.
Unions said the cuts will hit poorer workers and pensioners hard but there was broad political support for Monti's plan, which is expected to be approved in parliament before Christmas.
"The choice isn't between a light package and a tough package, it's between a tough package today and the risk of bankruptcy for the country tomorrow," Angelino Alfano, secretary of the centre-right PDL party told SkyTG24 television.
With Italy, the euro zone's third-largest economy, close to a debt emergency that would destroy Europe's financial defenses, EU leaders will meet in Brussels this week hoping to agree steps to bind the bloc more closely with tougher fiscal rules.
SEVERE
Sources present at discussions on the new fiscal measures said they would total around 20 billion euros ($27 billion).
An extra 4 billion euros would come from automatic cuts to tax breaks and welfare measures outlined but not clearly identified in the austerity package presented by the previous government.
Monti will have to balance the competing needs of showing budget rigor while not choking off growth, without which it will be impossible to reduce a 1.8-trillion-euro debt mountain.
About half of the overall package will be used to cut the budget deficit and help balance the budget by 2013 despite the economic downturn and rising borrowing costs.
The other half will free up resources to try to regenerate Italy's chronically stagnant economy, which is widely expected to go into recession next year.
Changes to pensions will be key in the new reform plan, with eligibility requirements toughened up for so-called seniority pensions which are based on a combination of workers' age and the years for which they have paid contributions.
Programmed cuts to the national health service budget are expected to be accelerated by one year, to reduce spending by 2.5 billion euros in 2012 and 5 billion euros from 2013, a local government source said.
A local housing tax (ICI) may also be reintroduced, bringing in estimated revenue of at least 3.5 billion euros per year, although this total could increase depending on possible adjustments to the assessment basis on which the tax is raised.
Other expected measures include further increases in value added tax rates and a ban on cash transactions above 500 euros in an effort to tackle tax evasion.
But the package will contain no reform of job contracts which hinder companies from laying off workers, a measure seen as key to overhauling the labor market but which is bitterly opposed by unions.
($1 = 0.7446 euros)
(Writing By Catherine Hornby and James Mackenzie; Editing by Sophie Hares)
Source: http://us.rd.yahoo.com/dailynews/rss/europe/*http%3A//news.yahoo.com/s/nm/20111204/bs_nm/us_italy
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